Kininogens

Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.

Also Known As:

Kininogen; Prekinins; Prokinins; T-Kininogen; Thiostatin; Kininogen Cystatins; T Kininogen; Cystatins, Kininogen

Pharmalogical Action Categories:

Cysteine Proteinase Inhibitors

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Kinins: 2029
      - Kininogens: 453
  - Blood Proteins: 12459
    - Blood Coagulation Factors: 5376
      - Kininogens: 453
  - Protein Precursors: 37
    - Kininogens: 453
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Kinins: 2029
      - Kininogens: 453
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Kinins: 2029
    - Kininogens: 453
- Blood Coagulation Factors: 5376
  - Kininogens: 453
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Kinins: 2029
      - Kininogens: 453

E Bonamigo Selected Research

E Bonamigo Research Topics

Disease

Drug/Important Bio-Agent (IBA)